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Research Project: MIWDE

  Methods for Integrating Wet-Lab and Dry-Lab Experiments

Abstract: Means that help a better integration between wet-lab and dry-lab experiments shall be developed, e.g., in the area of parameter estimation, or model validation.

  Research Project Information
Runtime: May 01, 2008 until Jan 01, 2011
Contractor(s): DFG (RTG dIEM oSIRIS til May 2010)

This project has been started in the research training group dIEM oSIRIS. The work on the projects partially continues in the context of the CoSA project.

 

General information

The different phases of the systems biology life cycle shall be analyzed and means that help a better integration between wet-lab and dry-lab experiments shall be developed, e.g., in the area of parameter estimation, or model validation.

 

Status

The work is currently based on the modelling and simulation tool JAMES II, which is permanently extended to meet the challenges arising out of this project. Ongoing work is, e.g., the integration of further efficient algorithms and data structures for efficient simulations, the integration of sequential and parallel optimization algorithms for model parameter optimization, the integration of mechanisms for model validation, the integration of additional modelling languages to ease the creation of models, on reliable modelling and simulation experiments, and on general flexible, scalable and reusable architectures for these.

Currently we are working on a better integration of wet-lab and dry-lab experiments by integrating the results achieved so far.